CITRA TRAMADOL 50MG 50TABS

Description CITRA TRAMADOL 50MG 50TABS   Tramadol is a centrally acting opioid pain reliever. It is a pure non-selective agonist at μ, δ and κ opioid receptors with a higher affinity for the μ receptor, thereby altering the perception of pain and the emotional response to it. Mu receptors are widely distributed throughout the CNS, especially in the limbic system, thalamus, striatum, hypothalamus, and midbrain, as well as in laminae I, II, IV, and V of the dorsal horn in the spinal cord. Kappa receptors are located mainly in the medulla and the cerebral cortex. Other mechanisms that contribute to its analgesic effect are inhibition of neuronal reuptake of norepinephrine and serotonin. Tramadol has an antitussive effect. Gastrointestinal motility is not affected. The effects of tramadol on the major and minor circulation and on the heart are scarce and clinically irrelevant, therefore there is no limitation for its use in coronary heart disease accompanied by pain. At therapeutic doses it does not cause alterations in the respiratory system. The potency of tramadol is reported to be 1/10 to 1/6 that of morphine. CITRA TRAMADOL 50MG 50TABS